Mitochondrial proteins NIP-SNAP-1 and -2 are a target for the immunomodulatory activity of clarithromycin, which involves NF-κB-mediated cytokine production

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• 作者：Soh Yamamoto^a ; Noriko Ogasawara^a ; ^b ; Keisuke Yamamoto^b ; Chika Uemura^c ; Yoshiaki Takaya^c ; Tsukasa Shiraishi^a ; Toyotaka Sato^a ; Shin Hashimoto^d ; Hiroyuki Tsutsumi^d ; Kenichi Takano^b ; Tetsuo Himi^b ; Shin-ichi Yokota^a ; ^{syokota@sapmed.ac.jp}
• 关键词：NIP-SNAP ; Macrolide antibiotics ; Clarithromycin ; Innate immunity ; Proinflammatory cytokines ; Mitochondria
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：12 February 2017
• 年：2017
• 卷：483
• 期：3
• 页码：911-916
• 全文大小：943 K
• 卷排序：483

文摘

Clarithromycin (CAM)-conjugating Sepharose was created using a CAM derivative. Mitochondrial NIP-SNAP-1, -2 and VLCAD were identified as CAM binding proteins. Knockdown of NIP-SNAPs suppressed LPS-induced IL-8 and IL-6, and NF-κB activation.