Syntaxin 8 is required for efficient lytic granule trafficking in cytotoxic T lymphocytes
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- 作者：Shruthi S. Bhata ; shruthi_s_bhat@yahoo.co.in" class="auth_mail" title="E-mail the corresponding author ; Kim S. Friedmanna ; 1 ; kim.friedmann@uks.eu" class="auth_mail" title="E-mail the corresponding author ; Arne Knö ; rcka ; 1 ; arne.knoerck@uni-saarland.de" class="auth_mail" title="E-mail the corresponding author ; Cora Hoxhaa ; cora.hoxha@uks.eu" class="auth_mail" title="E-mail the corresponding author ; Petra Leidingerc ; p.leidinger@mx.uni-saarland.de" class="auth_mail" title="E-mail the corresponding author ; Christina Backesd ; c.backes@mx.uni-saarland.de" class="auth_mail" title="E-mail the corresponding author ; Eckart Meesec ; hgemee@uniklinik-saarland.de" class="auth_mail" title="E-mail the corresponding author ; Andreas Kellerd ; andreas.keller@ccb.uni-saarland.de" class="auth_mail" title="E-mail the corresponding author ; Jens Rettigb ; jrettig@uks.eu" class="auth_mail" title="E-mail the corresponding author ; Markus Hotha ; markus.hoth@uks.eu" class="auth_mail" title="E-mail the corresponding author ; Bin Qua ; bin.qu@uks.eu" class="auth_mail" title="E-mail the corresponding author ; Eva C. Schwarza ; eva.schwarz@uks.eu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CHX ; cycloheximide ; CTL ; Cytotoxic T lymphocytes ; E ; T ; effector to target ratio ; FHL ; familial HLH ; HLH ; hemophagocytic lymphohistiocytosis ; LDH ; lactate dehydrogenase ; LG ; lytic granules ; IS ; immunological synapse ; qRT-PCR ; quantitative real time polymerase chain reaction ; SEA ; staphylococcal enterotoxin A ; Stx8 ; Syntaxin 8 ; SNARE ; soluble N-ethylmaleimide-sensitive factor attachment protein receptor ; TCR ; T cell receptor ; TGN ; trans-Golgi network
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：1863
- 期：7
- 页码：1653-1664
- 全文大小：1591 K
文摘
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Stx8 is among the most abundant Q-SNAREs in human cytotoxic T lymphocytes.
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Stx8 is required for proper and timely sorting and trafficking of cytotoxic molecules.
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Cytotoxicity in Stx8 down-regulated human cytotoxic T lymphocytes is impaired.