Development of novel cilostazol-loaded solid SNEDDS using a SPG membrane emulsification technique: Physicochemical characterization and in vivo evaluation

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• 作者：Omer Mustapha^a ; ^b ; ¹ ; Kyung Soo Kim^a ; ¹ ; Shumaila Shafique^c ; Dong Shik Kim^a ; Sung Giu Jin^a ; Youn Gee Seo^d ; Yu Seok Youn^e ; Kyung Taek Oh^f ; Beom-Jin Lee^g ; Young Joon Park^g ; Chul Soon Yong^d ; Jong Oh Kim^d ; ^{jongohkim@yu.ac.kr} ; Han-Gon Choi^a ; ^{hangon@hanyang.ac.kr}
• 关键词：Cilostazol ; Solid self-nanoemulsifying drug delivery system ; Shirasu porous glass membrane ; Membrane emulsification ; Emulsion droplet size ; Solubility ; Bioavailability
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：150
• 期：Complete
• 页码：216-222
• 全文大小：1232 K
• 卷排序：150

文摘

Cilostazol-loaded solid SNEDDS was prepared using membrane emulsification technique. It was prepared with calcium silicate as a solid carrier. It provided smaller and more uniform nanoemulsions than the non-emulsified SNEDDS. It gave higher drug solubility and dissolution than the non-emulsified SNEDDS. This SNEDDS improved the oral bioavailability of cilostazol.