Neuronal SOCE: Myth or Reality?

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• 作者：Bo Lu¹ ; Marc Fivaz¹ ; ² ; ^{marc.fivaz@duke-nus.edu.sg" class="auth_mail" title="E-mail the corresponding author}
• 关键词：SOCE ; STIM ; neuron ; calcium imaging ; endoplasmic reticulum
• 刊名：Trends in Cell Biology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：26
• 期：12
• 页码：890-893
• 全文大小：1546 K

文摘

Store-operated Ca²⁺ entry (SOCE) is the primary Ca²⁺ influx pathway in non-excitable cells. Long thought to be absent in nerve cells, neuronal SOCE is gaining popularity. We argue here that the evidence for SOCE in neurons remains contentious, mostly because SOCE imaging assays are inadequate in these cells.