Mutant SOD1 accumulation in sensory neurons does not associate with endoplasmic reticulum stress features: Implications for differential vulnerability of sensory and motor neurons to SOD1 toxicity
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- 作者：Michela Taiana ; Jenny Sassone ; jenny.sassone@istituto-besta.it" class="auth_mail" title="E-mail the corresponding author ; Giuseppe Lauria
- 关键词：Amyotrophic lateral sclerosis ; SOD1 ; Dorsal root ganglion neurons ; Endoplasmic reticulum stress ; Unfolded protein response
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：3 August 2016
- 年：2016
- 卷：627
- 期：Complete
- 页码：107-114
- 全文大小：3842 K
文摘
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Similarly to motor neurons, DRG neurons of SOD1G93A mice accumulate mutant/misfolded SOD1.
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DRG neurons of SOD1G93A mice do not suffer from ER stress and UPR activation.
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DRG neurons do not express detectable levels of the SOD1 interactor derlin-1.
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These differences may underlie the different vulnerability of motor and sensory neurons to SOD1.