Colorectal cancer: comparative analysis of clinical and pathological characteristics in patients aged above and below 45 years of age and impact on prognosis

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• 作者：Joana Sofia Gomes Pestana^a ; Sandra Fá ; tima Fernandes Martins^a ; ^b ; ^c ; ^{sandramartins@ecsaude.uminho.pt}
• 关键词：Colorectal cancer ; Age ; Clinicopathological features ; Survival
• 刊名：Journal of Coloproctology
• 出版年：2016
• 出版时间：October-December 2016
• 年：2016
• 卷：36
• 期：4
• 页码：196-202
• 全文大小：826 K
• 卷排序：36

文摘

Colorectal cancer, in Portugal, presents as the second most common cancer and of cancer death cause. CRC is a disease of the elderly; however, there has been an increase of incidence in younger patients and doubts have emerged about its behavior, characteristics and prognosis in this group.MethodsIn this study, we have evaluated a sample of 512 patients diagnosed with colorectal cancer submitted to surgical treatment in the period between January 1st, 2005 and January 1st, 2010, through a comparative clinical, pathological and survival analysis of patients under and over 45 years old (Groups I and II respectively).ResultsGroup I patients accounted for 5.5% of the sample. There was a predominance of males and the most common site was the left colon in both age groups. In the younger group, the histological type presents with a predominance of tumors with a mucinous component and with signet ring cells (p = 0.001), however, there was no difference in terms of overall survival and disease-free survival.ConclusionIn this study, colorectal cancer at younger ages shows similar characteristics to those of older patients.