High-intensity resistance training in multiple sclerosis ‿An exploratory study of effects on immune markers in blood and cerebrospinal fluid, and on mood, fatigue, health-related quality of life, muscle strength, walking and cognition
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- 作者：Marie Kierkegaarda ; b ; Marie.Kierkegaard@ki.se" class="auth_mail" title="E-mail the corresponding author ; Ingrid E. Lundbergc ; Ingrid.Lundberg@ki.se" class="auth_mail" title="E-mail the corresponding author ; Tomas Olssond ; e ; Tomas.Olsson@ki.se" class="auth_mail" title="E-mail the corresponding author ; Sverker Johanssona ; b ; Sverker.Johansson@ki.se" class="auth_mail" title="E-mail the corresponding author ; Sofia Ygbergf ; Sofia.Ygberg@karolinska.se" class="auth_mail" title="E-mail the corresponding author ; Christina Opavaa ; g ; Christina.Opava@ki.se" class="auth_mail" title="E-mail the corresponding author ; Lotta Widé ; n Holmqvista ; b ; h ; Lotta.Holmqvist@ki.se" class="auth_mail" title="E-mail the corresponding author ; Fredrik Piehld ; e ; Fredrik.Piehl@ki.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：CIS ; checklist individual strength ; CNS ; central nervous system ; CSF ; cerebrospinal fluid ; EDSS ; expanded disability status scale ; HADS ; hospital and anxiety depression scale ; HRQL ; health-related quality of life ; IL ; interleukin ; MS ; multiple sclerosis ; MSIS-29 ; MS impact scale ; 1RM ; one-repetition maximum ; RRMS ; relapsing&ndash ; remitting multiple sclerosis ; RCT ; randomized controlled trial ; TNF ; tumor necrosis factor ; TST ; timed-stands test ; VAS ; visual analog scale
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：362
- 期：Complete
- 页码：251-257
- 全文大小：354 K
文摘
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High-intensity resistance training was evaluated in patients with multiple sclerosis.
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The training protocol was feasible for multiple sclerosis patients with low disability.
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Fatigue and health-related quality of life were clinically relevantly improved.
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Positive effects were found in peripheral pro-inflammatory cytokine levels.
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These results provide a basis for a larger randomized controlled trial.