Curcumin as a therapeutic agent in the chemoprevention of inflammatory bowel disease
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- 作者：Remya Sreedhar1 ; sreedharremya@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Somasundaram Arumugam1 ; Rajarajan A. Thandavarayan2 ; Vengadeshprabhu Karuppagounder1 ; Kenichi Watanabe1 ; watanabe@nupals.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Drug Discovery Today
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：21
- 期：5
- 页码：843-849
- 全文大小：457 K
文摘
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Inflammatory bowel diseases are the chronic recurrent inflammation of the intestine.
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An imbalance of pro- and anti-inflammatory cytokines worsens inflammation in the gut.
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Oxidative stress and ER stress mediated apoptosis may lead to intestinal damage.
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Curcumin can reduce the cytokine infiltration during inflammation.
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Antioxidant properties of curcumin also alleviates the disease progression.