Signalling mechanism for somatostatin receptor 5-mediated suppression of AMPA responses in rat retinal ganglion cells
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- 作者：Qin-Qin Deng ; Wen-Long Sheng ; Gong Zhang ; Shi-Jun Weng ; Xiong-Li Yang ; Yong-Mei Zhong ; ymzhong@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Somatostatin ; sst5 ; AMPA receptor ; Retinal ganglion cells ; Neuromodulation
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：107
- 期：Complete
- 页码：215-226
- 全文大小：2253 K
文摘
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Somatostatin (SRIF) receptor 5 (sst5) is expressed in retinal ganglion cells (GCs).
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SRIF suppresses AMPA currents of GCs via sst5 activation.
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Gi/o/cAMP-PKA/Ca2+/CaM/calcineurin/PP1 pathway mediates the SRIF effect on GCs.
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SRIF suppresses AMPA receptor-meditated light-evoked EPSCs of GCs.