Somatostatin receptor 5 is a prominent regulator of signaling pathways in cells with coexpression of Cannabinoid receptors 1
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- 作者：Shenglong Zou ; Rishi K. Somvanshi ; Ujendra Kumar ; ujendra.kumar@ubc.ca
- 关键词：AD ; Alzheimer&rsquo ; s disease ; cAMP ; cyclic adenosine monophosphate ; CB1R ; Cannabinoid receptor 1 ; CNS ; central nervous system ; co-IP ; co-immunoprecipitation ; Cy3 ; cyanine 3 ; D2R ; dopamine receptor 2 ; ERK1/2 ; extracellular signal-regulated kinase 1/2 ; FITC ; fluorescein isothiocyanate ; FSK ; forskolin ; GPCR ; G protein-coupled receptor ; HA ; hemagglutinin ; hCB1R ; human cannabinoid receptor 1 ; HD ; Huntington&rsquo ; s disease ; hSSTR5 ; human somatostatin receptor 5 ; IBMX ; 3-isobutyl-1-methylxanthine ; PA
- 刊名：Neuroscience
- 出版年：2017
- 出版时间：6 January 2017
- 年：2017
- 卷：340
- 期：Complete
- 页码：218-231
- 全文大小：3093 K
- 卷排序：340
文摘
SSTR5 and CB1R exist as constitutive heterodimers in rat brain regions and cotransfected HEK-293 cells. Concurrent receptor activation leads to preferential disruption of SSTR5/CB1R heterodimer and formation of SSTR5 homodimer. SSTR5 plays the major role in the regulation of cAMP/PKA/ERK1/2 signaling pathways in cotransfected cells. Time course of PI3K phosphorylation is altered upon concurrent receptor activation.