Breaking the ice: urine proteomics of medullary sponge kidney disease

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• 作者：Somchai Chutipongtanate¹ ; ^{schuti.rama@gmail.com} ; ^{s_keing@hotmail.com}
• 关键词：biomarker ; medullary sponge kidney ; renal stone ; urine
• 刊名：Kidney International
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：91
• 期：2
• 页码：281-283
• 全文大小：739 K
• 卷排序：91

文摘

Urinary proteomics is a promising tool for biomarker investigation, particularly in complex kidney diseases. Fabris and colleagues report that urinary laminin subunit alpha-2 is a potential diagnostic marker of medullary sponge kidney (MSK) disease by using a label-free quantitative proteomics platform and a clinically compatible enzyme-linked immunosorbent assay. The neglected issue of stone pathogenesis was also evidenced. This commentary discusses several considerations in biomarker validation, and how urinary proteomics breaks new ground in MSK research.