Rbf Regulates Drosophila Spermatogenesis via Control of Somatic Stem and Progenitor Cell Fate in the Larval Testis

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• 作者：Nicole Dominado¹ ; ² ; John E. La Marca³ ; Nicole A. Siddall¹ ; ² ; James Heaney¹ ; ² ; Mai Tran² ; Yu Cai⁴ ; ⁵ ; Fengwei Yu⁴ ; Hongyan Wang⁶ ; ⁷ ; W. Gregory Somers³ ; Leonie M. Quinn² ; ⁸ ; ^{l.quinn@unimelb.edu.au} ; Gary R. Hime¹ ; ² ; ^{g.hime@unimelb.edu.au}
• 关键词：retinoblastoma protein ; stem cell ; stem cell niche ; self-renewal ; proliferation ; germline ; testis ; Drosophila
• 刊名：Stem Cell Reports
• 出版年：2016
• 出版时间：13 December 2016
• 年：2016
• 卷：7
• 期：6
• 页码：1152-1163
• 全文大小：7043 K
• 卷排序：7

文摘

Rbf null testes exhibit failure of germline stem cells to differentiate Rbf expression in somatic cells of L3 testes rescues the GSC differentiation defect Somatic Rbf RNAi disrupts cyst stem cell and germline stem cell differentiation Somatic depletion of E2f1 rescues Rbf germline proliferation and differentiation