Use of tosylated glycerol carbonate to access N-glycerylated aza-aromatic species

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• 作者：Gyt? Vilkauskait?^a ; Sonata Krik&scaron ; tolaityt?^b ; Osvaldas Paliulis^a ; Patrick Rollin^c ; Arnaud Tatibouë ; t^c ; ^{arnaud.tatibouet@univ-orleans.fr} ; Algirdas &Scaron ; a?kus^a ; ^{algirdas.sackus@ktu.lt}
• 关键词：Glycerol ; Heterocycles ; Tosylates ; Carbonates ; Carbamates ; Oxiranes
• 刊名：Tetrahedron
• 出版年：2013
• 出版时间：6 May, 2013
• 年：2013
• 卷：69
• 期：18
• 页码：3721-3727
• 全文大小：277 K

文摘

Tosylated glycerol carbonate was used for N-glyceryl functionalization of diverse aza-aromatic systems. Depending on the pK_a of the aza-heterocycle and the reaction conditions applied, original N-alkylated or N-acylated aza-heterocyclic derivatives were obtained. Those compounds carry an electrophilic appendage¡ªeither carbonate or epoxide¡ªwhich allows further useful transformations.