iPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-α Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy
详细信息 查看全文
- 作者：Yuelin Zhang1 ; Zhendong Yu2 ; Dan Jiang3 ; Xiaoting Liang1 ; Songyan Liao1 ; Zhao Zhang3 ; Wensheng Yue1 ; Xiang Li1 ; Sin-Ming Chiu1 ; Yuet-Hung Chai1 ; 4 ; Yingmin Liang1 ; Yenyen Chow1 ; Shuo Han3 ; Aimin Xu1 ; 4 ; Hung-Fat Tse1 ; 4 ; 5 ; hftse@hku.hk" class="auth_mail" title="E-mail the corresponding author ; Qizhou Lian1 ; 3 ; 4 ; 6 ; qzlian@hku.hk" class="auth_mail" title="E-mail the corresponding author
- 关键词：anthracyclines ; cardiomyopathy ; mesenchymal stem cells ; induced pluripotent stem cells
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：11 October 2016
- 年：2016
- 卷：7
- 期：4
- 页码：749-763
- 全文大小：3565 K
文摘
- •
Functional mitochondrial transfer of iPSC-MSCs attenuates Dox-induced cardiomyopathy
- •
High intrinsic Miro1 in iPSC-MSCs contributes to efficacious mitochondrial transfer
- •
iPSC-MSCs are highly responsive to TNF-α-induced tunneling nanotube formation