The Homeobox Transcription Factor RHOX10 Drives Mouse Spermatogonial Stem Cell Establishment
详细信息 查看全文
- 作者：Hye-Won Song1 ; Anilkumar Bettegowda1 ; Blue B. Lake2 ; Adrienne H. Zhao1 ; David Skarbrevik1 ; Eric Babajanian1 ; Meena Sukhwani3 ; Eleen Y. Shum1 ; Mimi H. Phan1 ; Terra-Dawn M. Plank1 ; Marcy E. Richardson1 ; Madhuvanthi Ramaiah1 ; Vaishnavi Sridhar1 ; Dirk G. de Rooij4 ; Kyle E. Orwig3 ; Kun Zhang2 ; Miles F. Wilkinson1 ; 5 ; 6 ; mfwilkinson@ucsd.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：spermatogonial stem cells ; spermatogonia ; spermatogenesis ; germ cell ; germ line stem cell ; homeobox ; Rhox ; transcription factor ; gonocytes ; prospermatogonia
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：27 September 2016
- 年：2016
- 卷：17
- 期：1
- 页码：149-164
- 全文大小：5032 K
文摘
- •
Deletion of a large X-linked homeobox gene cluster causes spermatogenic defects
- •
One member of this cluster—Rhox10—drives the initial establishment of SSCs
- •
Rhox10 acts by promoting the differentiation of pro-spermatogonia into SSCs
- •
Rhox10 also drives the migration of pro-spermatonia into the SSC niche