Synthesis, anti-tobacco mosaic virus and cucumber mosaic virus activity, and 3D-QSAR study of novel 1,4-pentadien-3-one derivatives containing 4-thioquinazoline moiety
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- 作者：Chengwen Long1 ; Pei Li1 ; Meihang Chen ; Liangrun Dong ; Deyu Hu ; fcc.dyhu@gzu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Baoan Song ; songbaoan22@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：1 ; 4-Pentadien-3-one ; 4-Thioquinazoline ; Antiviral activity ; 3D-QSAR
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2015
- 出版时间：18 September 2015
- 年：2015
- 卷：102
- 期：Complete
- 页码：639-647
- 全文大小：894 K
文摘
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Novel 1,4-pentadien-3-one derivatives containing 4-thioquinazoline moiety were designed and synthesized.
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The target compounds showed good antiviral activities against TMV and CMV.
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EC50 values of class="boldFont">7a were 124.3 and 365.5 渭g/mL for the protection activity against TMV and CMV.
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EC50 value of class="boldFont">7j was 213.5 渭g/mL for the curative activity against TMV.
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3D-QSAR study was analyzed on the basis of the curative activity against TMV.