We used melanocyte cell line (HEMn-LP) and melanoma cell lines (A375 and A2058) to model malignant progression.
We integrated miRNA and mRNA sequencing data to characterize the melanoma transcriptome.
Combined network and pathway analysis identified miRNAs regulating melanoma malignancy.
Analysis of clinical samples and public datasets validated our bioinformatic data on novel and mature miRNAs.