Lipoxin A4 attenuates LPS-induced mouse acute lung injury via Nrf2-mediated E-cadherin expression in airway epithelial cells
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- 作者：Xue Chenga ; 1 ; Songqing Heb ; c ; 1 ; Jing Yuand ; e ; 1 ; Shuo Miaoa ; Hongyu Gaof ; Jingnong Zhangg ; Yang Lid ; e ; Wei Pengh ; Ping Wua ; wpingwp@mails.tjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：LXA4 ; Nrf2 ; E-Cadherin ; Airway epithelium ; Acute lung injury
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：93
- 期：Complete
- 页码：52-66
- 全文大小：13234 K
文摘
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An Nrf-2 mediated mechanism for LXA4 protection on E-cadherin in airway epithelium is proposed.
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Fluorescence resonance energy transfer analysis indicted that LXA4 promoted the dissociation of Nrf2 and its negative regulator, Keap1.
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LXA4 could regulate the mitochondrial redox status in LPS-treated mice from a higher oxidative state to a more reduced state.