- 作者：M貌nica Guxens ; Agnes M.M. Sonnenschein-van der Voort ; Henning Tiemeier ; Albert Hofman ; Jordi Sunyer ; Johan C. de Jongste ; Vincent W.V. Jaddoe ; Liesbeth Duijts
- 关键词：Anxiety ; asthma ; child ; preschool ; child development ; cohort studies ; depression ; prospective studies ; stress ; psychological
- 刊名：Journal of Allergy and Clinical Immunology
- 出版年：January, 2014
- 年：2014
- 卷：133
- 期：1
- 页码：59-67.e12
- 全文大小：389 K
Background
Maternal psychological distress during pregnancy might affect fetal lung development and subsequently predispose children to childhood asthma.Objective
We sought to assess the associations of maternal psychological distress during pregnancy with early childhood wheezing.
Methods
We performed a population-based prospective cohort study among 4848 children. We assessed maternal and paternal psychological distress at the second trimester of gestation and 3 years after delivery and maternal psychological distress at 2 and 6 months after delivery by using the Brief Symptom Inventory questionnaire. Wheezing in the children was annually examined by using questionnaires from 1 to 4 years. Physician-diagnosed ever asthma was reported at 6 years.
Results
Mothers with psychological distress during pregnancy had increased odds of wheezing in their children from 1 to 4 years of life (overall distress: odds ratio [OR], 1.60 [95% CI, 1.32-1.93]; depression: OR, 1.46 [95% CI, 1.20-1.77]; and anxiety: OR, 1.39 [95% CI, 1.15-1.67]). We observed similar positive associations with the number of wheezing episodes, wheezing patterns, and physician-diagnosed asthma at 6 years. Paternal distress during pregnancy and maternal and paternal distress after delivery did not affect these results and were not associated with childhood wheezing.
Conclusion
Maternal psychological distress during pregnancy is associated with increased odds of wheezing in their children during the first 6 years of life independent of paternal psychological distress during pregnancy and maternal and paternal psychological distress after delivery. These results suggest a possible intrauterine programming effect of maternal psychological distress leading to respiratory morbidity.