KRAS Engages AGO2 to Enhance Cellular Transformation
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- 作者：Sunita Shankar1 ; 2 ; Sethuramasundaram Pitchiaya1 ; 2 ; 3 ; Rohit Malik1 ; 2 ; Vishal Kothari1 ; 2 ; Yasuyuki Hosono1 ; 2 ; Anastasia K. Yocum1 ; 2 ; Harika Gundlapalli1 ; 2 ; Yasmine White4 ; Ari Firestone4 ; Xuhong Cao1 ; 5 ; Saravana M. Dhanasekaran1 ; 2 ; Jeanne A. Stuckey6 ; 7 ; Gideon Bollag8 ; Kevin Shannon4 ; Nils G. Walter3 ; Chandan Kumar-Sinha1 ; 2 ; Arul M. Chinnaiyan1 ; 2 ; 5 ; 9 ; 10 ; arul@umich.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：cancer ; KRAS ; EIF2C2 ; Argonaute 2 ; RNA silencing
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：16 February 2016
- 年：2016
- 卷：14
- 期：6
- 页码：1448-1461
- 全文大小：3850 K
文摘
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RAS interacts with AGO2 in the membrane component of the endoplasmic reticulum
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The N terminus of AGO2 directly binds the Switch II domain of RAS
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Oncogenic KRAS association inhibits AGO2-mediated microRNA duplex unwinding
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AGO2 interaction elevates oncogenic KRAS levels to enhance cellular transformation