Sequence-Structure-Function Classification of a Catalytically Diverse Oxidoreductase Superfamily in Mycobacteria
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- 作者：F. Hafna Ahmed1 ; Paul D. Carr1 ; Brendon M. Lee1 ; Livnat Afriat-Jurnou1 ; A. Elaaf Mohamed1 ; Nan-Sook Hong1 ; Jack Flanagan2 ; Matthew C. Taylor3 ; Chris Greening3 ; Colin J. Jackson1 ; colin.jackson@anu.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：FDOR ; flavin/deazaflavin oxidoreductases ; FMN ; flavin mononucleotide ; FAD ; flavin adenine dinucleotide ; PnPOx ; pyridoxine/pyridoxamine 5&prime ; -phosphate oxidase ; SSN ; sequence similarity networks
- 刊名：Journal of Molecular Biology
- 出版年：2015
- 出版时间：6 November 2015
- 年：2015
- 卷：427
- 期：22
- 页码：3554-3571
- 全文大小：2645 K
文摘
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Mycobacterial FDORs use a variety of cofactors.
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F420, flavin mononucleotide, flavin adenine dinucleotide, and heme are specifically bound by proteins of the same fold.
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Variations in substrate binding pockets and loops lead to functional specialization.
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Diverse functions include quinone, fatty acid and biliverdin reductases, and heme oxygenases.
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These findings form a framework to understand FDORs role in mycobacterial survival.