- 作者：Ji Hye Yoon ; HyangHee Kim ; Sang Won Seo ; Juhee Chin ; Jung-Hyun Kim ; Kyung-Han Lee ; Yong Wook Kim ; Eun Sook Park ; Mee Kyung Suh ; Duk L. Na
- 关键词：Hangul ; Writing ; Dysgraphia ; Linguistic ; Nonlinguistic ; Visuospatial ; Alzheimer's disease ; PET
- 刊名：Journal of the Neurological Sciences
- 出版年：2012
- 出版时间：15 September, 2012
- 年：2012
- 卷：320
- 期：1-2
- 页码：72-78
- 全文大小：1007 K
Background
In writing, linguistic (i.e., spelling) and nonlinguistic (i.e., arranging strokes or letters) functions are processed by the left and right hemispheres, respectively. The configuration of Korean alphabet, ¡®Hangul¡¯ invokes nonlinguistic, visuospatial functions that other writing systems use less extensively. Patients with Alzheimer's disease (AD) have bilateral involvement of temporoparietal-frontal areas that are responsible for processing language and visuospatial functions.Objectives
The aim of this study was to examine the nature of Hangul writing dysfunction, which may be associated with bilateral hemispheric impairments in AD.
Methods
A sample of 75 patients with AD and 20 healthy controls (HC) performed a Hangul writing task. Neuroimaging positron emission tomography (PET) data of 22 patients were utilized to measure the regional brain glucose metabolism associated with Hangul writing.
Results
The writing performance of the AD group was significantly reduced and different types of errors were observed as the disease got worse. Glucose hypometabolism correlated with Hangul writing impairment was located in the right occipitotemporal lobe and left temporoparietal lobe.
Conclusions
The PET findings demonstrate that impairment in Hangul writing performance in Korean AD patients is closely related to a functional decline in both the right and left hemispheres. The study provides a unique contribution to the knowledge of dysgraphia in a non-alphabetical writing system as well as the underlying neuropathology of dysgraphic features in such languages.