Self-reported cognitive problems in testicular cancer patients: Relation to neuropsychological performance, fatigue, and psychological distress

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• 作者：Tone Skaali^a ; ^b ; ^{tone.skaali@oslo-universitetssykehus.no"" rel=""nofollow} ; Sophie D. Foss&#xe5 ; ^a ; ^b ; Stein Andersson^c ; Milada Cvancarova^a ; ^b ; Carl W. Langberg^d ; Gustav Lehne^e ; Alv A. Dahl^a ; ^b
• 关键词：Chemotherapy ; Fatigue ; Prospective study ; Psychological distress ; Self-reported cognitive problems ; Testicular cancer patients
• 刊名：Journal of Psychosomatic Research
• 出版年：2011
• 出版时间：May 2011
• 年：2011
• 卷：70
• 期：5
• 页码：403-410
• 全文大小：126 K

文摘

Objective

There is a concern about negative cognitive effects of systemic chemotherapy. We prospectively explored self-reported cognitive problems in testicular cancer patients (TCPs) treated with and without chemotherapy.

Methods

One hundred and twenty-two TCPs were interviewed about concentration and memory problems shortly after orchidectomy but before any additional treatment (baseline), and then at a median of 1 year after end of treatment (follow-up). Symptoms of psychological distress, fatigue, and peripheral neurotoxicity were assessed by questionnaires, and patients also underwent neuropsychological testing. Self-reported cognitive problems were compared between three treatments groups: no chemotherapy, one cycle of chemotherapy, and multiple cycles of chemotherapy. Variables associated with an increase of self-reported cognitive problems from baseline to follow-up were explored.

Results

Significantly larger proportions of TCPs in the two chemotherapy groups had an increase of self-reported cognitive problems from baseline to follow-up compared to the no-chemotherapy group. Increase of self-reported cognitive problems was significantly associated with psychological distress, fatigue, lower level of education, and Raynaud-like symptoms, but not with a decline in neuropsychological test performance.

Conclusion

In this explorative study of TCPs, an increase of self-reported cognitive problems from baseline to 1-year follow-up was associated with chemotherapy and with symptoms of fatigue and psychological distress at follow-up, while no significant association was found with a decline in neuropsychological test performance.