Therapeutic potential of GABA_B receptor ligands in drug addiction, anxiety, depression and other CNS disorders

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• 作者：Kushal Kumar ; Sorabh Sharma ; Puneet Kumar ; Rahul Deshmukh
• 关键词：GABA ; Anxiety ; Addiction ; Depression ; Neurodegenerative disorders ; CNS disorders
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2013
• 出版时间：September, 2013
• 年：2013
• 卷：110
• 期：Complete
• 页码：174-184
• 全文大小：1023 K

文摘

Glutamate and ¦Ã-aminobutyric acid (GABA) are the major excitatory and inhibitory neurotransmitter systems, respectively in the central nervous system (CNS). Dysregulation, in any of these or both, has been implicated in various CNS disorders. GABA acts via ionotropic (GABA_A and GABA_C receptor) and metabotropic (GABA_B) receptor. Dysregulation of GABAergic signaling and alteration in GABA_B receptor expression has been implicated in various CNS disorders. Clinically, baclofen-a GABA_B receptor agonist is available for the treatment of spasticity, dystonia etc., associated with various neurological disorders. Moreover, GABA_B receptor ligands has also been suggested to be beneficial in various neuropsychiatric and neurodegenerative disorders. The present review is aimed to discuss the role of GABA_B receptors and the possible outcomes of GABA_B receptor modulation in CNS disorders.