SUMO Signaling by Hypoxic Inactivation of SUMO-Specific Isopeptidases
详细信息 查看全文
- 作者：Kathrin Kunz1 ; 3 ; Kristina Wagner1 ; 3 ; Luca Mendler1 ; Soraya Hö ; lper1 ; Nathalie Dehne2 ; Stefan Mü ; ller1 ; 4 ; ste.mueller@em.uni-frankfurt.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：SUMO ; SUMO isopeptidase ; SENP ; hypoxia ; proteomics
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：13 September 2016
- 年：2016
- 卷：16
- 期：11
- 页码：3075-3086
- 全文大小：2213 K
文摘
- •
The activity of distinct SUMO isopeptidases is impaired under hypoxia
- •
SUMO modification of a subset of target proteins is altered in hypoxia
- •
Transcriptional regulator BHLHE40 is a hypoxic SUMO target
- •
SUMOylation of BHLHE40 may contribute to metabolic reprogramming under hypoxia