Sox21 deletion in mice causes postnatal growth deficiency without physiological disruption of hypothalamic-pituitary endocrine axes

详细信息    查看全文

• 作者：Leonard Y.M. Cheung^a ; Hideyuki Okano^b ; Sally A. Camper^a ; ^{scamper@med.umich.edu}
• 关键词：SOX21 ; SoxB1 ; Pituitary ; Hypothalamus ; Metabolism
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：213-223
• 全文大小：5087 K
• 卷排序：439

文摘

This is the first study to explore the reduced growth in Sox21-null mice. SOX21 is expressed in the hypothalamus. Loss of Sox21 causes postnatal growth reduction independent of hypothalamic-pituitary axes. Sox21−/− mice have increased energy expenditure but normal physical activity and food intake.