Developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin may alter LH release patterns by abolishing sex differences in GABA/glutamate cell number and modifying the transcriptome of the male anteroventral periventricular nucleus
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- 作者：Javier Del Pino Sans&dagger ; ; Kelsey J. Clements ; Alexander Suvorov&Dagger ; ; Sudha Krishnan§ ; ; Hillary L. Adams ; Sandra L. Petersen ; spetersen@vasci.umass.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AhR ; arylhydrocarbon receptor ; AR ; androgen receptors ; AVPV ; anteroventral periventricular nucleus ; ER ; estrogen receptors ; GnRH ; gonadotropin releasing-hormone ; LH ; luteinizing hormone ; QPCR ; quantitative real-time polymerase chain reaction ; T ; testosterone ; TCDD ; 2 ; 3 ; 7 ; 8 ; -tetrachlorodibenzo-p-dioxin
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：4 August 2016
- 年：2016
- 卷：329
- 期：Complete
- 页码：239-253
- 全文大小：1136 K
文摘
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Neonatal TCDD exposure abolishes sex differences in AVPV GABA/Glutamate neuronal population.
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TCDD likely regulates genes important for neuron development, synaptic transmission and sterol biosynthesis.
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TCDD regulates gene sets that are also regulated by ER, AR, Srebp1 and 2, and E2f.
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Cugbp2, Prph, Nefh, Sox11 and Mmp9 are sex-specific genes found in this study to be regulated by TCDD.