Spatio-temporal expression of Sox genes in murine palatogenesis

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• 作者：Momoko Watanabe^a ; ^b ; ¹ ; Katsushige Kawasaki^a ; ^c ; ^d ; ¹ ; Maiko Kawasaki^a ; ^c ; Thantrira Portaveetus^c ; Shelly Oommen^c ; James Blackburn^c ; Takahiro Nagai^b ; Atsushi Kitamura^b ; Atsushi Nishikawa^b ; Yasumitsu Kodama^b ; Ritsuo Takagi^b ; Takeyasu Maeda^a ; Paul T. Sharpe^c ; Atsushi Ohazama^a ; ^c ; ^{atsushiohazama@dent.niigata-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Sox ; Palatal development ; In situ hybridisation
• 刊名：Gene Expression Patterns
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：21
• 期：2
• 页码：111-118
• 全文大小：11365 K

文摘

Members of the Sox gene family play critical roles in many biological processes including organogenesis. We carried out comparative in situ hybridisation analysis of seventeen Sox genes (Sox1-14, 17, 18 and 21) during murine palatogenesis from initiation to fusion of the palatal shelves above the dorsal side of the tongue. At palatal shelf initiation (E12.5), the localized expression of six Sox genes (Sox2, 5, 6, 9, 12 and 13) was observed in the shelves, whereas Sox4 and Sox11 showed ubiquitious expression. During the down-growth of palatal shelves (E13.5), Sox4, Sox5, and Sox9 exhibited restricted expression to the interior side of the palatal shelves facing the tongue. Following elevation of the palatal shelves (E14.5), Sox2, Sox11 and Sox21 expression was present in the midline epithelial seam. We thus identify dynamic spatio-temporal expression of Sox gene family during the process of palatogenesis.