The role of SOX11 in mantle cell lymphoma

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• 作者：Ting-Xun Lu ; Jian-Yong Li ; Wei Xu
• 关键词：Mantle cell lymphoma ; SOX11 ; CCND1
• 刊名：Leukemia Research
• 出版年：November, 2013
• 年：2013
• 卷：37
• 期：11
• 页码：1412-1419
• 全文大小：1135 K

文摘

The mechanism of SOX11 function has been widely published recently mainly focused on histone modifications. Besides diagnostic value in mantle cell lymphoma (MCL), SOX11 has also prognostic significance. Although it can also be observed in a fraction of other T and B-cell lymphomas, a monoclonal antibody, called SOX11-C1, may improve the function of SOX11 in both diagnosis and prognosis evaluation. In addition, detection of modified SOX11 cDNA by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) has a higher sensitivity than traditional CCND1 examination in minimal residual disease (MRD) detection, which is an appealing option for predicting disease outcome and status.