刊名:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
出版年:2017
出版时间:March 2017
年:2017
卷:1863
期:3
页码:781-792
全文大小:3077 K
卷排序:1863
文摘
RAGE deficiency attenuates AoV calcification in ApoE−/− mice via inhibition of ER stress. HMGB1 induces osteoblastic differentiation and calcification of AVICs through RAGE. ER stress-dependent Sox9 activation mediates the effect of HMGB1 on AVICs. RAGE deficiency protects against inflammation both in vitro and in vivo.