LGG supplementation improved dyslipidemia and hepatic steatosis in HFD-fed mice.
LGG restored gut microbiota dysbiosis caused by HFD feeding.
Hepatic expressions of lipogenic and pro-inflammatory genes were suppressed.
Expression of cholesterol efflux-related and bile acid synthetic genes was enhanced.
The effect was found to be mediated by suppression of FXR and FGF15 signaling.