SPAK plays a pathogenic role in IgA nephropathy through the activation of NF-κB/MAPKs signaling pathway
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- 作者：Tsai-Jung Lina ; Sung-Sen Yangb ; c ; d ; Kuo-Feng Huae ; Yu-Ling Tsaia ; Shih-Hua Linc ; Shuk-Man Kaa ; f ; g ; shukmanka@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sterile 20/SPS1-related proline/alanine-rich kinase ; IgA nephropathy ; IgA immune complexes ; Mesangial cells ; Knockout mice ; T cells ; Macrophages ; NF-κB/MAPKs signaling
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：214-224
- 全文大小：3549 K
文摘
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SPAK mediated the development of IgAN through the activation of NF-κB/MAPKs.
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Reduced production of proinflammatory cytokinesin SPAK KO-IgAN mice.
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Reduced activation of NF-κB/MAPKs in renal intrinsic cells incubated with IgA IC.