Potassium depletion stimulates Na-Cl cotransporter via phosphorylation and inactivation of the ubiquitin ligase Kelch-like 3
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- 作者：Kenichi Ishizawaa ; 1 ; Ning Xua ; b ; 1 ; Johannes Loffingc ; Richard P. Liftond ; Toshiro Fujitae ; Shunya Uchidaa ; Shigeru Shibataa ; e ; shigeru.shibata@med.teikyo-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hypokalemia ; Distal nephron ; Ubiquitin proteasome pathway ; Post-translational modification
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：25 November 2016
- 年：2016
- 卷：480
- 期：4
- 页码：745-751
- 全文大小：1197 K
文摘
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The study proposes a mechanism that low-K+ diet increases renal salt reabsorption.
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K+ depletion inactivates KLHL3 by phosphorylation and by decreasing total levels.
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Phosphorylation of KLHL3 by PKC is sufficient to prevent WNK4 degradation.
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Suppression of KLHL3 by low K+ increases WNK4 and activates NCC via SPAK/OSR1.