Effects of chronic constriction injury and spared nerve injury, two models of neuropathic pain, on the numbers of neurons and glia in the rostral ventromedial medulla
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- 作者：Mai Lan Leong1 ; Rebecca Speltz2 ; Martin Wessendorf ; martinw@umn.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CCI ; chronic constriction injury ; CNS ; central nervous system ; DLF ; dorsal portion of the lateral funiculus ; PBS ; phosphate-buffered saline ; RVM ; rostral ventromedial medulla ; SNI ; spared nerve injury ; SNL ; spinal nerve ligation ; TPH ; tryptophan hydroxylase
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：23 March 2016
- 年：2016
- 卷：617
- 期：Complete
- 页码：82-87
- 全文大小：1353 K
文摘
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We examined whether RVM neurons were lost in two models of neuropathic pain, chronic constriction injury (CCI) and spared nerve injury (SNI).
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Tactile hypersensitivity was observed after both CCI and SNI.
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RVM neuronal loss was not observed ten days after either CCI or SNI.
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RVM neuronal death would be expected to result in glial proliferation (gliosis). Gliosis was not observed 10 days after either CCI or SNI.
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We conclude that loss of RVM neurons is not required for development of hypersensitivity after CCI or SNI.