A new model of nerve injury in the rat reveals a role of Regulator of G protein Signaling 4 in tactile hypersensitivity
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- 作者：Giuliano Taccolaa ; b ; c ; 1 ; Pierre J Doyena ; 1 ; Jonathan Damblona ; Nejada Dingua ; b ; c ; Beatrice Ballarina ; Arnaud Steyaerta ; Anne des Rieuxd ; Patrice Forgeta ; Emmanuel Hermansa ; Barbara Bosiera ; Ronald Deumensa ; ronald.deumens@uclouvain.be" class="auth_mail" title="E-mail the corresponding author ; deumensr@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CB1 receptor ; cannabinoid type-1 receptor ; DRG ; dorsal root ganglion ; GFAP ; glial fibrillary acidic protein ; Iba1 ; ionized calcium-binding adapter molecule 1 ; MPE ; maximum-possible-effect ; mSNI ; modified spared nerve injury ; PWT ; paw withdrawal threshold ; RGS4 ; Regulator of G protein Signaling 4 ; SNI ; spared nerve injury ; SSI ; static sciatic index
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：286
- 期：Complete
- 页码：1-11
- 全文大小：1247 K
文摘
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Restricting peripheral nerve injury reduces prevalence of tactile hypersensitivity.
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Presence/absence of tactile hypersensitivity is correlated to RGS4 gene expression.
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Intrathecal RGS4 inhibition transiently reverses tactile hypersensitivity.
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Persistent tactile hypersensitivity is associated with increased glial reactivity.