Increased potency of an inactivated trivalent polio vaccine with oil-in-water emulsions

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• 作者：Susan L. Baldwin^a ; ^{sbaldwin@idri.org} ; Christopher B. Fox^a ; Mark A. Pallansch^b ; Rhea N. Coler^a ; Steven G. Reed^a ; ^c ; Martin Friede^d
• 关键词：IPV ; Adjuvant ; Oil-in-water
• 刊名：Vaccine
• 出版年：2011
• 出版时间：17 January 2011
• 年：2011
• 卷：29
• 期：4
• 页码：644-649
• 全文大小：248 K

文摘

The use of inactivated poliovirus vaccines (IPV) will be required to achieve, world-wide eradication of polio. The current expense of IPV is however prohibitive for, some countries, and therefore efforts to decrease the costs of the vaccine are a high, priority. Our results show that the addition of oil-in-water emulsion adjuvants to an, inactivated trivalent poliovirus vaccine are dose-sparing and are capable of enhancing, neutralizing antibody titers in the rat potency model.