Functional fluorescent nonporous silica nanoparticles as carriers for Pt(IV) anticancer prodrugs
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- 作者：Mauro Ravera ; mauro.ravera@uniupo.it" class="auth_mail" title="E-mail the corresponding author ; Elena Perin ; Elisabetta Gabano ; Ilaria Zanellato ; Guido Panzarasa ; Katia Sparnacci ; Michele Laus ; Domenico Osella
- 关键词：Drug delivery ; Nonporous silica nanoparticles ; Enhanced permeability and retention effect ; Pt(IV) prodrug ; Antiproliferative activity
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：151
- 期：Complete
- 页码：132-142
- 全文大小：1245 K
文摘
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Amino-decorated SiO2 nanoparticles were used for the delivery of antitumor prodrugs.
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Mono- and di-functionalized Pt(IV) complexes derived from cisplatin were loaded.
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Only conjugates obtained from monosuccinato Pt(IV) afforded stable nanosuspensions.
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In the presence of reductants, the release of cisplatin was observed.
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Conjugates exhibited better antiproliferative activity than cisplatin and free complex.