Alterations of gene expression indicating effects on estrogen signaling and lipid homeostasis in seabream hepatocytes exposed to extracts of seawater sampled from a coastal area of the central Adriatic Sea (Italy)

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• 作者：Paolo Cocci^a ; Martina Capriotti^a ; Gilberto Mosconi^a ; Alessandra Campanelli^b ; Emanuela Frapiccini^b ; Mauro Marini^b ; Giovanni Caprioli^c ; Gianni Sagratini^c ; Graziano Aretusi^d ; ^e ; Francesco Alessandro Palermo^a ; ^{francesco.palermo@unicam.it}
• 关键词：Endocrine disruption ; Oestrogen mimics ; Gene transcription ; Coastal waters ; Adriatic Sea ; Sparus aurata
• 刊名：Marine Environmental Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：123
• 期：Complete
• 页码：25-37
• 全文大小：3545 K
• 卷排序：123

文摘

ERα and VTG were induced by samples from transect I in two of the areas studied. Water samples taken at certain areas induced expression profiles of PPARα/SCD1A. Gene biomarkers were not modulated by exposure to samples from the reference site. Biomarkers responses correlated with spatial distribution of PAHs/PCBs levels. Data suggest EDCs contamination for the upstream and downstream river site samples.