Bio-inspired amino acid oxidation by a non-heme iron catalyst

详细信息    查看全文

• 作者：Szabina Gó ; ger^a ; Dó ; ra Bogá ; th^a ; Gá ; bor Bará ; th^a ; A. Jalila Simaan^b ; Gá ; bor Speier^a ; Jó ; zsef Kaizer^a ; ^{kaizer@almos.vein.hu}
• 关键词：Iron ; Salen ; Amino acids ; Oxidation ; ACC oxidase ; Catalysis
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2013
• 出版时间：June, 2013
• 年：2013
• 卷：123
• 期：Complete
• 页码：46-52
• 全文大小：1322 K

文摘

This study reports the kinetics and mechanism of Fe(III)-catalyzed oxidative decarboxylation and deamination of a series of acyclic (¦Á-aminoisobutyric acid, ¦Á-(methylamino)isobutyric acid, alanine, norvaline, and 2-aminobutyric acid) and cyclic (1-aminocyclopropane-1-carboxylic acid, 1-amino-1-cyclobutanecarboxylic acid, 1-aminocyclopentanecarboxylic acid, and 1-aminocyclohexanecarboxylicacid) amino acids using hydrogen peroxide, t-butyl hydroperoxide, iodosylbenzene, m-chloroperbenzoic acid, and peroxomonosulphate as oxidant in 75 % DMF-25 % water solvent mixture. Model complex [Fe^IVO(SALEN)]^?+ (SALENH₂: N,N¡ä-bis(salicylidene)ethylenediamine) was generated by the reaction of Fe^III(SALEN)Cl and H₂O₂ in CH₃CN at 278 K as reported earlier. This method provided us high-valent oxoiron species, stable enough to ensure the direct observation of the reaction with amino acids.