Allele-specific transcription factor binding in liver and cervix cells unveils many likely drivers of GWAS signals
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- 作者：Marco Cavallia ; Gang Pana ; Helena Norda ; 1 ; Emelie Wallé ; n Arzta ; 2 ; Ola Wallermana ; b ; Claes Wadeliusa ; claes.wadelius@igp.uu.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：Allele-specific regulation ; Association to GWAS/eQTLs ; Functional variants
- 刊名：Genomics
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：107
- 期：6
- 页码：248-254
- 全文大小：675 K
文摘
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Use of ChIP-seq data to pinpoint non-coding functional regulatory elements.
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Collections of putative regulatory variants in HepG2 and HeLa-S3 based on allele-specific TF binding (AS-SNPs).
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AS-SNPs are likely drivers of the associations observed in GWAS/eQTLs analyses.