Sex-Specific Effects of Adrenergic-Induced Left Ventricular Remodeling in Spontaneously Hypertensive Rats
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- 作者：Frederic S. Michel ; PhD ; frederic.michel@wits.ac.za ; Mhlengi Magubane ; MS ; Lebogang Mokotedi ; MS ; Gavin R. Norton ; MD ; PhD ; Angela J. Woodiwiss ; PhD
- 关键词：LV dilation ; eccentric LV remodeling ; sex ; adrenergic stimulation
- 刊名：Journal of Cardiac Failure
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：23
- 期：2
- 页码：161-168
- 全文大小：786 K
- 卷排序：23
文摘
The role of sex on β-adrenergic–induced dilation in hypertension was assessed. β-Adrenergic stimulation leads to dilation only in male hypertensive rats. An increased fibrosis is involved in the β-adrenergic–induced dilation in males. Dilation precedes systolic chamber dysfunction in male hypertensive rats.