Enantio- and Diastereodivergent Synthesis of All Four Diastereomers of the 2,6-Disubstituted 3-Piperidinol Chiral Building Block
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Enantio- and diastereodivergent synthesis of all four diastereomers of 2,6-disubstituted 3-piperidinol has been achieved. The versatility of these compounds as the chiral building block for alkaloid synthesis has been demonstrated both by total synthesis of iso-6-cassine and by formal synthesis of prosopinine, cassine, and spectaline.