Analysis of circulating lipid-phase micronutrients in humans by HPLC: Review and overview of new developments
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- 作者：Jennifer F. Lai ; Adrian A. Franke
- 关键词：CoQ10 ; coenzyme Q10 ; TQ10 ; total coenzyme Q10 ; UN10 ; ubiquinone-10 ; UL10 ; ubiquinol-10 ; LPM ; lipid-phase micronutrients ; FD ; fluorescence detection ; ECD ; electrochemical detection ; TLS ; thermal lens spectrometry ; MS ; mass spectrometry ; MSMS ; tandem mass s
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2013
- 出版时间：15 July, 2013
- 年：2013
- 卷：931
- 期：Complete
- 页码：23-41
- 全文大小：1501 K
文摘
Retinol, tocopherols, coenzyme Q10, carotenoids, and vitamin D are lipophilic compounds shown to function as important health-protective agents by mitigating the damaging effects of oxidative and other injury. Scientific interest in evaluating these compounds has resurfaced in recent years, particularly in the nutritional, clinical and epidemiologic fields, and has precipitated the development of a multitude of new analytical techniques. This review considers recent developments in HPLC-based assays since 2007 for the simultaneous determination of these lipid-phase compounds utilizing exclusively serum or plasma as these matrices are mostly used in clinical and epidemiological investigations. We also provide an overview of blood measurements for selected carotenoids, tocopherols, coenzyme Q10 and retinol from the last 15 years of healthy umbilical cord blood, children, and adults.