Trait-related alterations of N-acetylaspartate in euthymic bipolar patients: A longitudinal proton magnetic resonance spectroscopy study
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- 作者：Burç ; Aydina ; burcaydin@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Ayşegü ; l Yurtb ; Necati Gö ; kmenc ; Perry Renshawd ; David Olsone ; Ayşegü ; l Yildizf ; g
- 关键词：ACC ; anterior cingular cortex ; BD ; bipolar disorder ; CGI-Mania ; Clinical Global Impressions-Bipolar Version Severity of Mania ; Cho ; phosphorylcholine plus glycerophosphocholine ; DLPFC ; dorsolateral prefrontal cortex ; DMPFC ; dorsomedial prefrontal cortex ; DSM-IV ; diagnostic and statistical manual of mental disorders ; 4th edition ; FC ; frontal cortex ; FL ; frontal lobe ; Glx ; glutamate plus glutamine ; 1H MRS ; proton magnetic resonance spectroscopy ; HAMD-17 ; 17-item Hamilton Depression Rating Scale ; M
- 刊名：Journal of Affective Disorders
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：206
- 期：Complete
- 页码：315-320
- 全文大小：697 K
文摘
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Mood- and trait-related alterations in bipolar disorder continue to elicit further investigation.
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Dorsomedial prefrontal cortex N-acetylaspartate values were lower in euthymic patients.
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Dorsomedial prefrontal cortex N-acetylaspartate/Total creatine ratio was lower in euthymic patients.
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Psychiatric rating score changes did not correlate with brain metabolite changes.