1H-magnetic resonance spectroscopy study of glutamate-related abnormality in bipolar disorder

详细信息    查看全文

• 作者：Hiroko Kubo^a ; Masahito Nakataki^a ; ^{nktk@tokushima-u.ac.jp} ; Satsuki Sumitani^a ; ^b ; Jun-ichi Iga^a ; ^c ; Shusuke Numata^a ; Naomi Kameoka^a ; Shin-ya Watanabe^a ; Hidehiro Umehara^a ; Makoto Kinoshita^a ; Masatoshi Inoshita^a ; Mai Tamaru^a ; Masashi Ohta^a ; Chiaki Nakayama-Yamauchi^d ; Yasuhiro Funakoshi^d ; Masafumi Harada^e ; Tetsuro Ohmori^a
• 关键词：Bipolar disorder ; Glutamate ; Glutamine ; Lithium ; Sodium valproate ; Magnetic resonance spectroscopy
• 刊名：Journal of Affective Disorders
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：208
• 期：Complete
• 页码：139-144
• 全文大小：360 K
• 卷排序：208

文摘

We compared brain metabolite levels of BD patients and healthy controls using MRS. BD had elevated Glu, Gln, Gln/Glu, NAA, Cr& Cho in the ACC, Gln & Cho in the ltBG. These findings remained after participants of BD were limited to those with euthymia. Thus, activated glutamatergic neurotransmissionmay relate to BD’s pathophysiology. By removing the effects of Li and VPA, elevated Gln survived only in the ACC.