Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination
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- 作者：Jose Luis Olmos-Serrano1 ; 9 ; Hyo Jung Kang2 ; 3 ; 9 ; William A. Tyler1 ; 9 ; John C. Silbereis2 ; 9 ; Feng Cheng2 ; 4 ; Ying Zhu2 ; Mihovil Pletikos2 ; Lucija Jankovic-Rapan2 ; Nathan P. Cramer5 ; Zygmunt Galdzicki5 ; Joseph Goodliffe1 ; Alan Peters1 ; Claire Sethares1 ; Ivana Delalle6 ; Jeffrey A. Golden7 ; Tarik F. Haydar1 ; thaydar@bu.edu" class="auth_mail" title="E-mail the corresponding author ; Nenad Sestan2 ; 8 ; nenad.sestan@yale.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：brain development ; neurodevelopmental disorders ; neocortex ; glia ; gene expression ; genomics ; white matter
- 刊名：Neuron
- 出版年：2016
- 出版时间：16 March 2016
- 年：2016
- 卷：89
- 期：6
- 页码：1208-1222
- 全文大小：4920 K
文摘
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Genome-wide spatiotemporal dysregulation of gene expression is found in DS brains
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Transcriptome changes reflect altered oligodendrocyte development and myelination
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Oligodendrocyte differentiation and myelination is altered in DS model mice (Ts65Dn)
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Speed of action potential propagation is decreased in Ts65Dn neocortical white matter