‘Cytology-on-a-chip’ based sensors for monitoring of potentially malignant oral lesions
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- 作者：Timothy J. Abrama ; 1 ; Pierre N. Florianob ; 1 ; Nicolaos Christodoulidesa ; Robert Jamesc ; A. Ross Kerrd ; Martin H. Thornhille ; Spencer W. Reddingf ; Nadarajah Vigneswarang ; Paul M. Speighth ; Julie Vickc ; Craig Murdoche ; Christine Freemane ; Anne M. Hegartyi ; Katy D&rsquo ; Apicei ; Joan A. Pheland ; Patricia M. Corbyj ; Ismael Khoulyk ; Jerry Bouquotg ; Nagi M. Demianl ; Y. Etan Weinstockm ; Stephanie Rowanf ; Chih-Ko Yehf ; n ; H. Stan McGuffo ; Frank R. Millerp ; Surabhi Gaura ; Kailash Karthikeyana ; Leander Taylora ; Cathy Lea ; Michael Nguyena ; Humberto Talaveraa ; Rameez Rajaa ; Jorge Wonga ; John T. McDevitta ; q ; r ; mcdevitt@nyu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：PMOL ; potentially malignant oral lesion(s) ; OED ; oral epithelial dysplasia ; OSCC ; oral squamous cell carcinoma ; HCA ; high content analysis ; AUC ; area under the (receiver-operator characteristic) curve ; NC ratio ; nuclear-cytoplasmic area ratio
- 刊名：Oral Oncology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：60
- 期：Complete
- 页码：103-111
- 全文大小：1731 K
文摘
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Cytology-on-chip approach permits rapid molecular and morphometric analysis.
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Stable, robust predictive models created from single-cell data.
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Prognostic cytology features identified including cell circularity, Ki67 expression.
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Unique combination of parameters required for different diagnostic splits.