POTE protein, a cancer-testis antigen, is highly expressed in spermatids in human testis and is associated with apoptotic cells

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• 作者：Tapan K. Bera^a ; ^{BeraT@mail.nih.gov} ; Dawn A. Walker^a ; ^{walkerd@mail.nih.gov} ; Richard J. Sherins^b ; ¹ ; ^{rsherins@comcast.net} ; Ira Pastan^a ; ^{pastani@mail.nih.gov}
• 关键词：POTE gene family ; Spermatids ; Apoptosis ; Cleaved Caspase-3
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2012
• 出版时间：27 January 2012
• 年：2012
• 卷：417
• 期：4
• 页码：1271-1274
• 全文大小：1073 K

文摘

The POTE gene family encodes very closely related proteins that are highly expressed in testis and in many cancers. Recent studies indicate that the POTE proteins have a pro-apoptotic function. To examine if POTE is associated with cells that are undergoing apoptosis in testis, we determined the cellular location of POTE and of Cleaved Caspase-3 in testicular tissues from 26 azoospermic men. We found intense expression of POTE in round spermatids that are undergoing apoptosis, which are positive for Cleaved Caspase-3. This study suggests POTE may have a role in apoptosis in the human testis.