Spherical agglomerates of lactose with enhanced mechanical properties
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- 作者：Dejan Lame&scaron ; ić ; dejan.lamesic@ffa.uni-lj.si ; Odon Planin&scaron ; ek ; Zoran Lavrič ; Ilija Ilić
- 关键词：Spherical crystallization ; Spherical agglomerates ; Lactose ; Compactibility ; Compressibility
- 刊名：International Journal of Pharmaceutics
- 出版年：2017
- 出版时间：10 January 2017
- 年：2017
- 卷：516
- 期：1-2
- 页码：247-257
- 全文大小：2559 K
- 卷排序：516
文摘
The aim of this study was to prepare spherical agglomerates of lactose and to evaluate their physicochemical properties, flow properties, particle friability and compaction properties, and to compare them to commercially available types of lactose for direct compression (spray-dried, granulated and anhydrous β-lactose). Porous spherical agglomerates of α-lactose monohydrate with radially arranged prism-like primary particles were prepared exhibiting a high specific surface area. All types of lactose analysed had passable or better flow properties, except for anhydrous β-lactose, which had poor flowability. Particle friability was more pronounced in larger granulated lactose particles; however, particle structure was retained in all samples analysed. The mechanical properties of spherical agglomerates of lactose, in terms of compressibility, established with Walker analysis, and compactibility, established with a compactibility profile, were found to be superior to any commercially available types of lactose. Higher compactibility of spherical agglomerates of lactose is ascribed to significantly higher particle surface area due to a unique internal structure with higher susceptibility to fragmentation.