The hyaluronic acid inhibitor 4-methylumbelliferone is an NSMase2 activator—role of Ceramide in MU anti-tumor activity
详细信息 查看全文
- 作者：Jingdong Qina ; qjingdong@peds.bsd.uchicago.edu" class="auth_mail" title="E-mail the corresponding author ; John Kilkusa ; Glyn Dawsona ; b ; dawg@uchicago.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：DMEM ; Dulbecco's modified Eagle's medium ; DMSO ; dimethylsulfoxide ; fro ; fragilis ossium ; HA ; hyaluronic acid ; HAS ; HA synthase ; HPTLC ; high performance thin-layer chromatography ; LC&ndash ; MS/MS ; liquid chromatography&ndash ; tandem mass spectrometry ; MES ; 2-(N-morpholino) ethanesulfonic acid ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyltetrazolium bromide ; MU ; 4-methylumbelliforone ; MβCD ; methyl-beta-cyclodextrin ; NSMase2 ; neutral sphingomyelinase2 ; PP2A ; protein phosphatase 2A ; sGAG ; sulfated-g
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：1861
- 期：2
- 页码：78-90
- 全文大小：1800 K
文摘
- •
MU activates neutral sphingomelinase2 and elevates ceramides level in tumor cells.
- •
Elevated ceramides inhibit HA synthesis, cell migration and invasion, and induce apoptosis of tumor cells.
- •
NSMase2/Ceramide initiate MU mediated anticancer, suggesting that ceramides play a key role in the ability of a tumor to become aggressively metastatic and grow.